Acute Targeting of General Transcription Factor IIB Restricts Cardiac Hypertrophy via Selective Inhibition of Gene Transcription Sayed et al: Anti-TFIIB Inhibits Cardiac Hypertrophy
نویسندگان
چکیده
Correspondence to Maha Abdellatif, M.B.ChB, PhD and Danish Sayed, MD, PhD Cardiovascular Research Institute Department of Cell Biology and Molecular Medicine University of Medicine and Dentistry of New Jersey 185 S Orange Ave, Newark, NJ 07103. Maha Abdellatif Tel: (973) 972-1254 Fax: (973) 972-7489 E-mail: [email protected] Danish Sayed Tel: (973) 972-1208 Fax: (973) 972-7489 E-mail: [email protected]
منابع مشابه
Acute targeting of general transcription factor IIB restricts cardiac hypertrophy via selective inhibition of gene transcription.
BACKGROUND We previously reported that specialized and housekeeping genes are differentially regulated via de novo recruitment and pause-release of RNA polymerase II, respectively, during cardiac hypertrophy. However, the significance of this finding remains to be examined. Therefore, the purpose of this study was to determine the mechanisms that differentially regulate these gene groups and ex...
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BACKGROUND MicroRNAs (miR) are small, posttranscriptional regulators, expressed as part of a longer primary transcript, following which they undergo nuclear and cytoplasmic processing by Drosha and Dicer, respectively, to form the functional mature ~20mer that gets incorporated into the silencing complex. Others and we have shown that mature miR-1 levels decrease with pressure-induced cardiac h...
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تاریخ انتشار 2014